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| [WR] 06/22/2010 - Ed Gant expected to miss first 4 games of season ( Suspension ) | |
| [T] 06/07/2010 - Quinn Ojinnaka expected to miss first game of season ( Suspension ) | | [LB] 07/08/2010 - Robert James expected to miss first 4 games of the regular season ( Suspension ) | |
| [FS] 07/21/2010 - Ed Reed expected to miss first 6 regular season games ( Hip ) | |
| [LB] 06/10/2010 - Thomas Davis out indefinitely ( Knee ) | | [DT] 07/04/2010 - Hollis Thomas expected to miss first 8 games ( Suspension ) | |
| (!)[RB] 06/30/2010 - Cedric Benson "?" Sunday vs. New England ( Possible Suspension ) | |
| [DE] 07/11/2010 - Copeland Bryan IR ( Knee ) | |
| [DE] 07/18/2010 - Johnny Jolly suspended for entire season ( Suspension ) | |
| [LB] 05/08/2010 - Brian Cushing expected to miss first 4 games ( Suspension ) | |
| [DB] 06/26/2010 - Chad Jones out indefinitely ( Leg ) | |
| [WR] 04/13/2010 - Santonio Holmes expected to miss first 4 regular-season games ( Suspension ) | |
| [DB] 06/02/2010 - Marlin Jackson out for season ( Achilles ) | |
| (!)[QB] 04/21/2010 - Ben Roethlisberger expected to miss 4-6 games ( Suspension ) | | [OT] 06/29/2010 - Willie Colon out for season ( Achilles ) | |
| [WR] 07/01/2010 - Vincent Jackson expected to miss first 3 regular season games ( Suspension ) | |
| [LB] 07/17/2010 - Leroy Hill expected to miss Sept. 12 vs. San Francisco ( Suspension ) | |
| [CB] 06/17/2010 - Roderick Hood IR ( ACL ) | | [OLB] 06/16/2010 - Gerald McRath has been suspended for the first four games of the season ( Suspension ) |
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